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During oogenesis, an extensive epigenetic reprogramming occurs. This process is of major importance, as oocyte methylation can affect gene expression after fertilization.

The cognition and modelling group is an interdisciplinary research group with many national and international collaborations. We work mainly on cognitive impairment in multiple sclerosis patients.

Inherited metabolic disorders of the liver (IMLD) are a heterogeneous group of rare diseases caused by a single defective enzyme in a metabolic pathway of hepatocytes. This often leads to the accumulation of toxic metabolites and the highly specific destruction of liver cells.

Non-alcoholic fatty liver disease (NAFLD) is the most prevalent liver disease worldwide and is characterized by excessive accumulation of lipids in the liver (steatosis).

Immunosenescence (IS) describes the set of changes that occur in the immune system, resulting in a weakened immune function as we age.

Glioblastoma is the most common brain tumor with a very bad prognosis.

Cancer immunotherapy aims to restore the response of our immune system to eradicate tumors. The development of immune checkpoint inhibitors has boosted the field, but it is clear that these drugs only work in a proportion of patients.

Pancreatic cancer has a dismal prognosis with an overall survival rate of less than 10%, and with few improvements in the last 50 years, partly due to a lack of in-depth knowledge of pancreas (cancer) biology.

Chronic liver disease results in fibrosis, thereby creating a suitable environment in which primary liver tumors develop. Furthermore, the liver is an important site for metastasis of other tumors such as colon, breast, lung and melanoma cancer.

Liver fibrosis is the pathological condition of the liver resulting from sustained wound healing in response to various causes of liver injury, including chronic alcohol abuse, viral infections or obesity.