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Chronic (post- and non-cancer) pain affects up to 30% of the Belgian population and its prevalence is much higher than any other chronic disease^1,2 , thereby far outnumbering diseases like cancer and diabetes.

Our research is focused on 'Exercise and the Brain in Health & Disease' on three levels: fundamental, applied/clinical and policy-making/benchmarking.

spermatogonial stem cells (SSCs). Our overall aim is to develop strategies to prevent male infertility after spermatogonial stem cell loss.

During oogenesis, an extensive epigenetic reprogramming occurs. This process is of major importance, as oocyte methylation can affect gene expression after fertilization.

The cognition and modelling group is an interdisciplinary research group with many national and international collaborations. We work mainly on cognitive impairment in multiple sclerosis patients.

Inherited metabolic disorders of the liver (IMLD) are a heterogeneous group of rare diseases caused by a single defective enzyme in a metabolic pathway of hepatocytes. This often leads to the accumulation of toxic metabolites and the highly specific destruction of liver cells.

Non-alcoholic fatty liver disease (NAFLD) is the most prevalent liver disease worldwide and is characterized by excessive accumulation of lipids in the liver (steatosis).

Immunosenescence (IS) describes the set of changes that occur in the immune system, resulting in a weakened immune function as we age.

Glioblastoma is the most common brain tumor with a very bad prognosis.

Cancer immunotherapy aims to restore the response of our immune system to eradicate tumors. The development of immune checkpoint inhibitors has boosted the field, but it is clear that these drugs only work in a proportion of patients.