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Pancreatic cancer has a dismal prognosis with an overall survival rate of less than 10%, and with few improvements in the last 50 years, partly due to a lack of in-depth knowledge of pancreas (cancer) biology.

Chronic liver disease results in fibrosis, thereby creating a suitable environment in which primary liver tumors develop. Furthermore, the liver is an important site for metastasis of other tumors such as colon, breast, lung and melanoma cancer.

Liver fibrosis is the pathological condition of the liver resulting from sustained wound healing in response to various causes of liver injury, including chronic alcohol abuse, viral infections or obesity.

Lung cancer is the leading cause of cancer-related death worldwide with non-small-cell lung cancer (NSCLC) being the most common subtype, accounting for approximately 85% of lung cancers.

Diabetes is a pandemic disorder characterized by hyperglycemia. Current diabetes treatments strive for glycemic control but fail to solve the underlying beta cell defect.

The Skin Immunology & Immune Tolerance Research Group (SKIN) has the unique combination of two interacting groups; the clinical and the translational research group. The clinical research focusses on clinically relevant research questions and improved treatments for the patients.

One of the research topics of our group is the study of biomineralisation i.e. the formation of minerals produced by living organisms. In this frame, in vivo CaOx crystallization leads to the formation of kidney and urinary stones, constituting a serious health problem to mankind.

Despite the intensive experimental work performed on peptide bond formation using silica, clays, alumina and other materials as catalysts, there is still no detailed molecular picture available for these processes.

The formation of nanostructured bio-organic interfaces has attracted a lot of attention recently in surface science worldwide because of its promise in fields in need of biocompatible materials, such as biosensors and biomaterials, but also in molecular electronics devices.

About one third of all new active pharmaceutical ingredients (API) in drug applications contain one or more fluorine substituents. Furthermore, the three-dimensional structure (i.e. stereochemistry) of those APIs is becoming significantly more complex.